**English Name:** G418 Sulfate, Geneticin, Antibiotic G418
**Other Names:** G-418 Sulfate, Antibiotic G-418
**CAS Number:** 108321-42-2
**Molecular Formula:** Câ‚‚â‚€Hâ‚„â‚€Nâ‚„Oâ‚â‚€ · 2Hâ‚‚SOâ‚„
**Molecular Weight:** 692.71 g/mol
**Grade:** Biotech Grade
**Titer:** ≥600 U/mg
**Absorbance A570 (100 mg/mL):** ≤0.1
**Absorbance A280 (1 mg/mL):** ≤0.015
**Appearance:** White powder
**Description:** G418 is an aminoglycoside antibiotic that is highly soluble in water and methanol. It is widely used in biochemical research for selecting prokaryotic and eukaryotic cells that have been transfected with the neomycin resistance gene. This makes it a crucial tool in genetic engineering, including applications such as gene transfer, gene knockout studies, and resistance screening in transgenic organisms.
**Storage:** Store at 2–8°C, away from light and moisture to maintain stability and potency.
G418 plays a vital role in molecular biology laboratories, particularly in the development of stable cell lines and the verification of successful gene integration. Its effectiveness in inhibiting protein synthesis in susceptible cells makes it an essential reagent in many experimental protocols. Always handle with care and follow appropriate safety guidelines when working with this compound.
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