[China Packaging Network News] Drugs like granules are relatively sensitive to external water vapor and require packaging with high moisture resistance. This article takes the packaging film of a certain brand of cold particles as the test object, and uses the W3/031 water vapor transmission rate tester independently developed by Jinan Languang Electromechanical Technology Co., Ltd. as the testing equipment, and the test principle and equipment of the test process and equipment. Parameters, etc. are analyzed to provide enterprises with a method for detecting the water vapor transmission rate of a soft plastic package.
Keywords: moisture resistance, moisture resistance, water vapor transmission rate, granules, medicines, soft plastic packaging, agglomeration, moldy
1, the meaning
The most prominent characteristics of granules when they are deteriorating are stickiness, agglomeration, mildew, and offensive odors. These problems are related to the increase of water content in medicines. The granules themselves have low moisture content, large surface area, and strong water absorption. If they are stored improperly, the above-mentioned deterioration will occur. Therefore, improving the storage environment of granules and reducing the humidity of the storage environment is an effective way to prevent deterioration of the drug and prolong its shelf life. This requires that the packaging material of granules has a low water vapor transmission rate, moisture resistance, and moisture resistance. good.
2, the status quo
Direct contact with granules of pharmaceutical packaging materials are common plastic composite film, aluminum composite film, aluminum plastic composite film, etc. After the drug into the packaging bag, and then placed in a paper packaging box for transportation and sales.
At present, domestic methods for measuring the water vapor transmission rate of soft plastic packaging include weighing method (cup method), electrolysis method, humidity method, and infrared sensor. The reference standards are GB 1037-1988 "Plastic film and Test method for steam permeability of sheets - Cup method, GB/T "Test method for moisture permeability of packaging materials", GB/T "Determination of water vapour permeability of plastic films and sheets - Electrolytic sensors Method, GB/T "Determination of Water Vapor Transmission Rate of Plastic Films and Sheets Humidity Sensor Method" (published, implemented on December 1, 2014), GB/T "plastic film and sheet water Determination of Vapor Transmission Rate by Infrared Detector Method". The standard referenced in this article is GB 1037-1988 "Plastic Film and Sheet Water Vapor Permeability Test Method Cup Method".
3, test sample
The sample tested was a plastic composite film for certain brands of cold particle packaging.
4, testing equipment
The test equipment used in this article is Labthink Languang W3/031 water vapor transmission rate tester.
4.1 Test principle
This equipment is developed using the weighing method test principle. During the test, the sample is clamped in a moisture permeable cup, and a certain humidity difference is formed on both sides of the sample. Under the effect of the difference in humidity, water vapor penetrates through the sample from the high humidity side to the low humidity side, and passes through the through hole. The wet cup weight is measured as a function of time, and the parameters such as the water vapor transmission rate of the sample can be obtained.
4.2 Application
(1) This equipment is suitable for testing the water vapor transmission rate of films, sheets, paper, cardboard, textiles, non-woven fabrics and other materials.
Films: various plastic films, plastic composite film, paper-plastic composite film, geomembrane, co-extruded film, aluminized film, aluminum foil, aluminum-plastic composite film, waterproof breathable film and other film-like materials.
Sheets: all kinds of engineering plastics, rubber, building materials, insulation materials and other sheet materials, such as PP sheet, PVC sheet, PVDC sheet, nylon sheet and so on.
(2) The device can also be applied to the inverted cup test of samples and the water vapor transmission rate test of liquid crystal display film, solar back sheet, sterile protective film, and beauty mask.
(3) The equipment meets many national and international standards such as GB 1037, GB/T 16928, ISO 2528, ASTM E96, ASTM D1653, TAPPI T464, DIN 53122-1, JIS Z0208, YBB00092003, and others.
4.3 Equipment Parameters
l The test range of the equipment is 0.1 ~ 10000 g/m2·24h and the resolution is 0.01 g/m2·24h.
l The device's temperature control range is 15°C ~ 55°C, temperature control accuracy is ±0.1°C, humidity control range is 10%RH ~ 98%RH, and humidity control accuracy is ±1%RH.
l The device is equipped with three moisture-permeable cups, and three moisture-permeable cups can be independently tested.
l The system adopts an intermittent weighing method that meets the requirements of the standard, and ensures that the humidity difference between the inside and outside of the moisture permeable cup is constant through the standard blowing wind speed.
l The equipment provides two kinds of quick calibration methods, standard film and standard weight, to ensure the accuracy and versatility of the test data.
l The equipment supports the test result comparison. The user sets the standard value and error range before the test is started. After the test is completed, the system automatically judges whether each test result is within the range of the standard error and informs the user intuitively.
l Supports LystemTM laboratory data sharing system. Test data and device information can be reported simply by setting up and operating, making it easy to centralize and systematically manage laboratory test data.
5, the test process
(1) Cut 3 specimens with a diameter of 74 mm from the sample surface.
(2) Place the coupons in three moisture permeable cups, respectively, and place them on the permeable glass holder inside the device, and close the test chamber door.
(3) Set parameters such as test temperature, humidity, and sample thickness in the dedicated software system for the device configuration. Click the test option to start the test.
(4) The equipment automatically calculates the water vapor transmission rate of the sample based on the monitoring results.
6, test results
The water vapor transmission rates of the three samples of plastic composite film samples for the packaging of cold particles used in this article were 1.095 g/m2·24h, 0.918 g/m2·24h, and 0.961 g/m2·24h, respectively.
7. Conclusion
In order to prevent deterioration of granules, the packaging material should have a low water vapor transmission rate. This article tested the packaging material of a cold granule by the W3/031 water vapor transmission rate tester. The test results are reproducible. Good, high precision, can really show the moisture resistance of packaging materials, so W3/031 water vapor transmission rate tester is a practical and efficient testing equipment. Jinan Languang Electromechanical Technology Co., Ltd. has always been committed to providing professional testing equipment and services to customers around the world. For more information about Labthink's testing equipment or services, you can log in or consult directly. Labthink looks forward to working with companies and institutions in the industry to increase technical exchanges and cooperation!